One study, published in the Lancet and presented at the European Association for the Study of Diabetes, tested the drug retatrutide in people who were overweight or obese and had Type 2 diabetes: a population in which weight-loss medications have historically been less effective. People who took the highest dose lost about 18.8% of their starting body weight, while people who took a placebo lost 5.1%. About a third of the people in the study who took the highest dose of retatrutide lost at least 25% of their body weight, compared to 3% of those on placebo over the study period of 1.5 years.
People in the study also showed improvement in their diabetes control. Of those who took the highest dose, 63% lowered their A1C to less than 6.5%—the threshold for diabetes—and lost at least 10% of their body weight.
Retatrutide targets three weight-related hormones: GLP-1, GIP, and glucagon. Since each has specific receptors in the body and brain, targeting all three may be contributing to the more potent effects on weight for people with diabetes than drugs that target GLP-1 alone, like Ozempic and Wegovy (semaglutide), or GLP-1 and GIP together, as Mounjaro and Zepbound (tirzepatide) do. Zepbound is approved to not only control weight but to also treat obstructive sleep apnea, and Wegovy and Ozempic are approved to reduce the risk of heart disease.
Eli Lilly says it plans to submit a request in early 2027 to the U.S. Food and Drug Administration to approve retatrutide based on these results.
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