The only previous meeting between the sides was a 6-1 thrashing at Russia 2018 but the Central American side have improved significantly since.
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The Three Lions will want to win the group and show their quality as they build momentum ahead of the round of 32.
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The Central American team have already been eliminated and will want to leave a mark at the tournament so they're not likely to sit as deep as Ghana.
Radio Times says... Panama 0-3 England
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