"There's an urgent need to address antibiotic resistance in gonorrhea, and discovering new antibiotics is one of the key strategies," Dr. Jeffrey Klausner, a clinical professor at the University of Southern California who was not involved with the work, told Live Science. "It's exciting to see the application of AI in this area of public health."
Gonorrhea bacteria, called Neisseria gonorrhoeae, often carry mutations that confer resistance to one or more antibiotics, limiting treatment options. The widely used antibiotic ceftriaxone remains the go-to drug, but resistance to this drug is soaring globally. For now, only 0.1% of cases in the U.S. are resistant, but rates are as high as 10% in some Chinese provinces and 27% in Hanoi, Vietnam.
So, in a study published June 17 in the journal Science Translational Medicine, researchers instead harnessed AI to expeditiously wade through a bevy of antibiotic candidates. They trained the AI models to spot potential antibiotics by studying patterns in the chemical properties of 1,755 clinically approved drugs that either do or don't treat drug-susceptible gonorrhea.
One of the most promising compounds that emerged was called MP20, which the researchers then put to the test.
It can be difficult to establish a gonorrhea infection in mice. (Image credit: dra_schwartz via Getty Images)
Additionally, "there is a large push, especially in the U.S. administration, to move away from animals and to use more human-organ-mimicking systems" to test new drugs, she added. (Many scientists are developing such laboratory models of the human body for drug testing, but those models aren't necessarily ready to replace animal testing yet.)
The researchers added gonorrhea bacteria to the chip's first layer, mimicking how the bug is sexually transmitted. Then, they administered MP20 through the flow channel, mimicking body-wide administration of the drug, to see if the antibiotic could cross through these different tissues and reach the bacteria.
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He noted that an antibiotic's effectiveness depends on the anatomical site infected by the bug. So the researchers will need to assess how effectively their compounds, if delivered via the bloodstream, can reach the penis, rectum, throat and vagina to treat gonorrhea at any of those sites.
This article is for informational purposes only and is not meant to offer medical advice.
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