During an April 2026 interview with Access Hollywood, alongside his Full House castmate, Jodie Sweetin, Stamos noted that he was cast as Jesse after starring on General Hospital as the character Blackie Parrish. The actor said that because he was a "big shot" on the soap opera, he believed he would also be the star of Full House, which premiered in 1987.
"I said, 'This is my show.' And we start reading and then this little one just starts doing the jokes and hitting every joke out of the park," recalled Stamos, gesturing to a smiling Sweetin. "I got maybe one or two laughs, you know, at the table. And I'm just slowly like sinking down."
"I remember running out to the payphones at the time and jamming in a quarter, calling my manager, 'Get me off this show,'" said Stamos.
In a 2023 interview with CBS Sunday Morning, Stamos suggested he wasn't all that happy about starring on Full House during its first season. He explained that he hadn't pictured himself acting on a family sitcom that wasn't getting the best reviews.
He then said he is "so proud of it now."
Stamos returned to play Jesse for the 2016 Netflix reboot, Fuller House, which ran for five seasons.
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