Wegovy pill, from Novo Nordisk, was the first oral GLP-1 drug to be approved by the FDA, in December 2025. Foundayo is the second. The first versions of GLP-1s were injectable drugs that people had to give themselves weekly.
As with the injectable forms of GLP-1s, Foundayo is available in six doses, ranging from 0.8mg to 17.2mg. In consultation with their doctors, patients start with the lowest dose and gradually work up to higher doses; not everyone may need to reach the highest dose.
People taking orforglipron do not need to restrict food or drink after taking the pill, says Skovronsky. (Wegovy pill is a peptide, and people taking the drug need to avoid eating or drinking for 30 minutes after taking the pill.) Orforglipron is a small molecule that the body can absorb quickly and get into the blood, where it reaches the necessary tissues, Skovronsky explains.
The promise of a pill
“We see Foundayo as a foundational GLP-1 therapy,” said Eli Lilly CEO David Ricks during a press briefing, explaining the name of the drug. Lilly’s studies show that Foundayo could be an effective maintenance therapy for people looking to sustain weight loss after using the injectable GLP-1s to reach a target weight, and Ricks said the company has “broad ambitions” for seeking additional indications for the drug, including sleep apnea, hypertension, and stress urinary incontinence, for which it plans to submit to the FDA in coming months and years.
For people covered by insurance, Ricks said the drug would cost no more than $25 for every prescription as long as people download a savings card from the company’s website.
The quick action means Foundayo will be available next week on Lilly Direct and in pharmacies. “Obesity is a massively scaled problem and affects 100 million people in the U.S. and up to 1 billion around the world,” says Skovronsky. “This is a population health problem and it needs a population health solution. We want to impact human health, and we have the opportunity to do that with this pill.”
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