The O's are just a point above the bottom three after a four-game winless run, including defeats in their last three games.
Watch Leyton Orient v Plymouth Argyle on Sky SportsThe gap to the top six is nine points as things stand but there is still plenty of third-tier football to be played in the 2025/26 campaign.
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Check out our live football on TV guide for the latest times and information.
Leyton Orient v Plymouth Argyle kick-off time
Leyton Orient v Plymouth Argyle will kick off at 7:45pm.
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How to live stream Leyton Orient v Plymouth Argyle online
Sky Sports customers can live stream the game via the Sky Go app on a variety of devices including most smartphones and tablets as part of their subscription.
NOW can be streamed through a computer or apps found on most smart TVs, phones and consoles. NOW is also available via TNT Sports.
Is Leyton Orient v Plymouth Argyle on radio?
Unfortunately this match will not be aired on national radio. Check your local BBC radio station for more information.
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Leyton Orient v Plymouth Argyle odds
In working partnership with the Radio Times, bet365 has provided the following betting odds for this event:
bet365 odds: Leyton Orient (6/4) Draw (12/5) Plymouth Argyle (17/10)*
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*Odds subject to change. 18+. T&Cs apply. GambleAware.org. Note – The bonus code RT365 does not change the offer amount in any way.
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