Van Der Beek died at the age of 48 on Wednesday, Feb. 11 following a battle with stage 3 colorectal cancer, the same illness to which Couric lost her first husband, Jay Monahan.
"This is heartbreaking," Couric, 69, wrote via Instagram.
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View this post on InstagramFollowing his death, Couric became a vocal advocate for colon cancer awareness, famously undergoing a colonoscopy procedure on-air on the Today show in 2000.
Van Der Beek underwent a colonoscopy in August 2023 that led to his diagnosis with stage 3 colorectal cancer, though he didn't publicly share the news until November 2024.
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Related: James Van Der Beek Previously Addressed Noticeable Change in His Appearance Before Death
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