Is It Safe To Take Vitamin A and E Supplements Together? ...Saudi Arabia

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Dr. Heather Hughes, PharmD, a pharmacist and the group vice president of health, wellness and nutrition at Walgreens, tells Parade that conditions like cystic fibrosis and Crohn’s disease can make it harder for the body to absorb fat-soluble vitamins like vitamin A and E, so individuals with these health conditions may want to consider taking vitamin A and E supplements. 

While severe vitamin A deficiency is rare in the U.S., Dr. Yoshua Quinones, MD, an internist with Medical Offices of Manhattan and a contributor to Lab Finder, says that there are certain people who can benefit from taking a vitamin A supplement. “People who can benefit from vitamin A supplements are those who are immunocompromised, malnourished, have intestinal malabsorption issues or severe liver disease,” he explains.

Related: This Common Vitamin Deficiency Could Be the Reason You're Always Tired, Experts Warn

Vitamin E

“Several studies have shown harmful effects of vitamin E supplementation,” says Dr. David Cutler, MD, a family medicine physician at Providence Saint John’s Health Center in Santa Monica, California. Dr. Cutler explains that there is a bleeding risk when vitamin E is combined with certain blood-thinning medications and adds that high-dose vitamin E supplements are associated with an increased risk of hemorrhagic strokes. 

“The safest, most effective way to assure adequate vitamin E is through a balanced, healthy diet which includes nuts, seeds, vegetable oils, leafy green vegetables and avocado. Supplements of vitamin E should not be taken routinely, but only if there is a documented deficiency, a known medical indication or where dietary intake cannot be assured. While many typical American diets do not contain the recommended daily allowance of vitamin E, the preferred way to correct this is with a better diet, rather than supplements,” Dr. Cutler says.

Is It Safe To Take Vitamin A and E Together?

If you are taking vitamin A and vitamin E supplements, it’s important to know how to safely integrate them into your routine. Dr. Hughes recommends talking to a doctor or pharmacist before starting any new vitamin, and warns against taking vitamin A and E in high doses. 

Related: Doctors Say You Should Avoid These 4 Popular Supplements—and Take These Instead

Remember, ideally you should meet your nutrient needs through diet, and both vitamin A and E are found in a wide range of foods that fit into any dietary style. But if blood tests show that you aren’t getting enough or you have a health condition that is preventing your body from absorbing them through the foods you eat, talk to your doctor before integrating supplements into your routine. That way, you can make sure you’re taking them safely and you're getting your money’s worth.

Related: In High Doses, Cardiologists Say This Heart-Healthy Supplement May Be Doing More Harm Than Good

Sources:

Dr. Yoshua Quinones, MD, internist with Medical Offices of Manhattan and a contributor to Lab FinderDr. Heather Hughes, PharmD, pharmacist and the group vice president of Health, Wellness & Nutrition at WalgreensDr. David Cutler, MD, family medicine physician at Providence Saint John’s Health Center in Santa Monica, CaliforniaVitamin A. StatPearlsVitamin E. StatPearls Vitamin A and Carotenoids. National Institutes of Health. Office of Dietary SupplementsVitamin E. National Institutes of Health. Office of Dietary SupplementsKaye, A. D., Thomassen, A. S., Mashaw, S. A., et al. (2025). Vitamin E (a-Tocopherol): Emerging Clinical Role and Adverse Risks of Supplementation in Adults. Cureus. 17(2):e78679. Jabbari, P., Yazdanpanah, O., Benjamin, D., et al. (2024). Supplement Use and Increased Risks of Cancer: Unveiling the Other Side of the Coin.Cancers. 16(5):880

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