Caleb Williams drove the Bears (11-5) down the field in the closing seconds and had one last shot for the win. But Bryce Huff forced him out of the pocket and his throw short-hopped Jahdae Walker in the end zone to seal a sixth straight victory for the 49ers (12-4).
That gave the 49ers a chance to win the NFC West and get a bye by beating Seattle (13-3) in the season finale on Saturday night. A win would give San Francisco home-field advantage and a chance to stay home all postseason, with the Super Bowl set to be played at Levi's Stadium on Feb. 8.
Purdy finished 24 for 33 for 303 yards, while Christian McCaffrey ran for 140 yards and a score and added 41 more receiving.
Neither defense could slow down the opposing offense for most of the night after a pick-6 by Chicago's T.J. Edwards on the first play. The Niners led 28-21 at halftime.
The Bears finally forced a punt and went ahead 38-35 on a short field goal by Cairo Santos with 5:22 to play when they couldn't convert on third down in the red zone.
Purdy answered his big mistake to start the game with a 65-yard touchdown drive capped by a 1-yard pass to Jake Tonges, and San Francisco moved the ball with ease all half.
Bears: LB Noah Sewell left in the third quarter with an ankle injury. ... DE Joe Tryon-Shoyinka (concussion) left the game. ... WR Olamide Zaccheaus was a late scratch with an illness.
Up next
Bears: Host Detroit on Sunday.
49ers: Host Seattle on Saturday night.
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