Two of the SEC’s hottest teams will meet Saturday when Alabama visits Missouri, and with SEC Nation in town and the Tigers sporting a pristine 5-0 record, this weekend’s game in Columbia is among the biggest in the program’s recent history.
Circa Sports released its opening lines for Week 7’s action Sunday, and the Crimson Tide are being listed as a narrow 4-point favorite heading into the ranked clash.
College FootballWeek 7 Opening Lines pic.twitter.com/6jlpLLmeaa
— Circa Sports (@CircaSports) October 5, 2025Despite Mizzou being the home side and the lone undefeated team in this game, Alabama gets the nod as the favorite thanks to its recent performances. Since an opening loss to Florida State, Kaleb DeBoer‘s team has ripped off dominant wins over Louisiana-Monroe, Wisconsin and Vanderbilt, with a hard-fought road victory over Georgia throw in for good measure.
But while Ty Simpson & Co. come into this one with plenty of momentum at their backs, so does Mizzou.
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Transfer portal additions such as tailback Ahmad Hardy, quarterback Beau Pribula and receiver Kevin Coleman Jr. have all exceeded expectations thus far, and that’s allowed the Tigers to get out to an unblemished start. A comeback win over Kansas and a methodical victory over South Carolina have highlighted the first month in COMO, and it’s also worth pointing out that Mizzou will close a six-game home stand with this game.
The Tigers and Tide will kick off at noon EST, with the game being televised by ABC.
Alabama opens as slight road favorite over Mizzou in Week 7 clash Saturday Down South.
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