Quarterback Brock Purdy will miss his third game of the season because of an injury to his toe. The Niners (3-1) also ruled out starting receivers Ricky Pearsall and Jauan Jennings for the division showdown, with Pearsall out because of a knee injury and Jennings with injuries to his ankle and ribs.
(L-R) Brock Purdy, Ricky Pearsall, Jauan Jennings Thearon W. Henderson/Sean Gardner/Logan Bowles/Getty ImagesMac Jones will start in Purdy's place. Jones won both starts in Purdy's absence earlier this season, throwing for 563 yards with four TDs and one interception in wins over New Orleans and Arizona.
Purdy struggled at times against the Jaguars, missing several throws high. He went 22 for 38 for 309 yards and two touchdowns, but also had two interceptions and lost a fumble on a potential game-winning drive late in the fourth quarter. Purdy said he wasn't sure what impact the injury had on his performance.
Jones said Tuesday he had been preparing as the starter and knows he will have a tough test against the Rams' defense.
Receiver Jordan Watkins (calf) and defensive end Robert Beal (ankle) also will be out for San Francisco, while rookie defensive tackle C.J. West is questionable with a broken thumb.
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