Week 4 of the 2025 NFL season arrives with a full Sunday slate on September 28, offering a mix of high-stakes matchups and intriguing betting opportunities. From an early morning clash in Dublin to a prime-time showdown in Dallas, these games provide a chance to capitalize on early season trends and team dynamics. Whether you’re eyeing spreads, totals, or moneylines, the odds reflect the intensity of teams finding their rhythm. This article explores the complete odds board, highlights the most compelling games, and offers insights to help you navigate your betting decisions. Consider how injuries, weather, and Week 3 results shape the lines, and ask yourself which underdogs might steal the spotlight.
NFL Week 4 Odds Overview
The Sunday schedule kicks off with the Minnesota Vikings facing the Pittsburgh Steelers in Ireland at 8:30 AM ET. Favorites hold firm in several matchups, but tight spreads signal competitive battles. The lowest total on the board is the Titans-Texans at 38.5 and could be an absolute defensive grind. Below is the full list of spreads, totals, and moneylines to guide your wagers:
Minnesota Vikings at Pittsburgh Steelers (8:30 AM ET): Vikings -2.5 (-115), Steelers +2.5 (-105); Total O/U 40.5 (-115/-105); Vikings -142, Steelers +120 Los Angeles Chargers at New York Giants (12:00 PM ET): Chargers -6 (-110), Giants +6 (-110); Total O/U 43.5 (-115/-105); Chargers -278, Giants +225 Cleveland Browns at Detroit Lions (12:00 PM ET): Browns +10 (-115), Lions -10 (-105); Total O/U 44.5 (-105/-115); Browns +400, Lions -535 Philadelphia Eagles at Tampa Bay Buccaneers (12:00 PM ET): Eagles -3.5 (-102), Buccaneers +3.5 (-118); Total O/U 44.5 (-105/-115); Eagles -192, Buccaneers +160 New Orleans Saints at Buffalo Bills (12:00 PM ET): Saints +15.5 (-112), Bills -15.5 (-108); Total O/U 47.5 (-115/-105); Saints +850, Bills -1450 Washington Commanders at Atlanta Falcons (12:00 PM ET): Commanders +2.5 (-115), Falcons -2.5 (-105); Total O/U 43.5 (-108/-112); Commanders +114, Falcons -135 Tennessee Titans at Houston Texans (12:00 PM ET): Titans +7 (-102), Texans -7 (-118); Total O/U 39.5 (-105/-115); Titans +320, Texans -410 Carolina Panthers at New England Patriots (12:00 PM ET): Panthers +5.5 (-112), Patriots -5.5 (-108); Total O/U 42.5 (-115/-105); Panthers +195, Patriots -238 Indianapolis Colts at Los Angeles Rams (3:05 PM ET): Colts +3.5 (-105), Rams -3.5 (-115); Total O/U 49.5 (-115/-105); Colts +160, Rams -192 Jacksonville Jaguars at San Francisco 49ers (3:05 PM ET): Jaguars +3 (-105), 49ers -3 (-115); Total O/U 46.5 (-120/+100); Jaguars +140, 49ers -166 Baltimore Ravens at Kansas City Chiefs (3:25 PM ET): Ravens -2.5 (-120), Chiefs +2.5 (+100); Total O/U 48.5 (-120/+100); Ravens -148, Chiefs +124 Chicago Bears at Las Vegas Raiders (3:25 PM ET): Bears +1.5 (-120), Raiders -1.5 (+100); Total O/U 47.5 (-120/+100); Bears -108, Raiders -112 Green Bay Packers at Dallas Cowboys (8:20 PM ET): Packers -7 (-105), Cowboys +7 (-115); Total O/U 47.5 (-105/-115); Packers -360, Cowboys +285These odds, sourced from major sportsbooks, highlight opportunities like the Bills’ massive -15.5 spread against the struggling Saints or the low-scoring Titans-Texans matchup. Use these to craft parlays or target player props that align with game flow.
Sep 7, 2025; Orchard Park, New York, USA; Buffalo Bills quarterback Josh Allen (17) -rtb for a touchdown during the fourth quarter against the Baltimore Ravens at Highmark Stadium. Mandatory Credit: Gregory Fisher-Imagn ImagesMust-Watch Games for Sunday
Certain matchups stand out for their playoff implications, rookie debuts, and revenge narratives. These five games promise excitement and betting value, drawing you into the heart of Week 4 action.
The Baltimore Ravens versus Kansas City Chiefs at 3:25 PM ET is the marquee matchup. Lamar Jackson and Patrick Mahomes, both leading 1-2 teams, battle to regain momentum. Baltimore’s ground game, averaging 150 yards per game, challenges Kansas City’s secondary, which struggled against contact last week. The Chiefs’ home-field advantage keeps it close, but the 48.5-point total suggests a high-scoring affair. Can the Ravens’ top-five defense contain Mahomes?
Green Bay Packers at Dallas Cowboys closes the night with drama. Micah Parsons, now a Packer, returns to Dallas, where his former team struggles without his pass-rushing prowess. Green Bay’s defense leads the league with pressure on 45 percent of dropbacks, while Dallas ranks near the bottom in sacks allowed.
Los Angeles Chargers at New York Giants features a rookie storyline. Jaxson Dart makes his first start for the 1-2 Giants, facing a Chargers defense that’s held opponents under 20 points twice. Los Angeles, undefeated at 3-0, relies on Justin Herbert to pick apart New York’s last-ranked zone coverage. The Chargers’ -6 spread looks promising, but will Dart spark an upset?
Aug 16, 2025; East Rutherford, New Jersey, USA; New York Giants quarterback Jaxson Dart (6) looks to pass as New York Jets linebacker Zaire Barnes (right) defends during the second half at MetLife Stadium. Mandatory Credit: Rich Barnes-Imagn ImagesPhiladelphia Eagles at Tampa Bay Buccaneers pits two 3-0 teams. Philly’s narrow victories contrast with Tampa’s clutch finishes. Jalen Hurts faces Todd Bowles’ aggressive blitzes, but the Eagles’ offensive line holds firm. Tampa’s injury-riddled defense allows 5.8 yards per play in the fourth quarter, giving Philly the edge to cover -3.5.
Cleveland Browns at Detroit Lions offers upset potential. Fresh off a Week 3 win over Green Bay, Cleveland’s +10 spread tempts bettors. Detroit’s home dominance is undeniable, but the Browns’ secondary, allowing just 3.8 yards per play, keeps this game tight. The under 44.5 total is a smart play in a defensive battle.
Which of these games will you prioritize for your betting card?
Key Matchup Insights
The Vikings-Steelers opener in Dublin sets the tone. Minnesota’s offense, averaging 28 points, faces a Pittsburgh run defense that tightened up after Week 1. With Harrison Smith back, the Vikings’ secondary could limit Rodgers. A rainy forecast pushes the total under 40.5, favoring Minnesota to cover -2.5.
For Chargers-Giants, Los Angeles’ 3-0 ATS record meets a Giants team starting a rookie. Herbert’s precision against zone defenses should lead to a 28-17 win, covering -6 and staying under 43.5. The Eagles-Buccaneers matchup hinges on Philly’s line neutralizing Tampa’s blitz, leading to a field-goal victory.
The Bills-Saints game screams blowout, with Buffalo’s Josh Allen exploiting New Orleans’ 0-3 skid. Take the Bills -15.5 and over 47.5. Commanders-Falcons Washington will again see the Commanders down their starting QB and the Falcons have a decent shot to get a win. Titans-Texans stays low-scoring, with Houston winning 20-10, making the under 39.5 a lock.
[US, Mexico & Canada customers only] Sep 5, 2025; Sao Paulo, BRAZIL; Los Angeles Chargers quarterback Justin Herbert (10) during the warm up before a NFL game against the Kansas City Chiefs at Corinthians Arena. Mandatory Credit: Amanda Perobelli/Reuters via Imagn ImagesBetting Predictions and Trends
Data-driven picks point to value in the Chargers -6 and Bears +1.5. For parlays, combine Eagles ML (-192) with Texans -7 (-118) for a plus-money payout. Prop bets like Josh Allen over 1.5 passing TDs offer upside. Watch injury reports, as their status shifts lines. Undefeated teams like Philly cover 80 percent of spreads early, while unders hit 60 percent in games with totals below 40.
FAQs About Week 4 Betting
What happens if rain impacts Vikings-Steelers? Wet conditions favor Minnesota’s run game, pushing the total under 40.5.Is Chiefs +124 a good moneyline bet? It’s tempting if Mahomes capitalizes on Baltimore’s run defense leaks.How does Jaxson Dart perform in his debut? Expect struggles, with interception props and rushing overs looking like the tempting bets.Why bet the under in Titans-Texans? Both teams rank in the bottom five in offensive yards, signaling a 20-10 grind.
Responsible Gambling and Bankroll Management
Your betting strategy starts with discipline. Set a weekly budget, risking no more than 5 percent of your bankroll per wager. Track every bet in a spreadsheet to identify patterns and avoid chasing losses. Take breaks after tough weeks to reset your mindset. Divide your bankroll into units, wagering one unit on spreads and half on props. Shop lines across sportsbooks to maximize value, and limit parlays to three legs or fewer. Staying consistent keeps you in the game for the long haul, ensuring betting remains enjoyable and sustainable.
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