Head coach Kyle Shanahan told reporters at a conference call that Bosa will undergo season-ending surgery on his right knee.
Bosa injured himself in the 1st half of the 49ers' victory against the Arizona Cardinals on Sunday. Television coverage of the game showed Bosa on the ground on the sideline after his injury, and later gesturing toward the stands after a visit to the medical tent with a "thumbs down" as he limped toward the locker room.
Nick Bosa #97 of the San Francisco 49ers walks to the locker room during the second quarter against the Arizona Cardinals at Levi's Stadium on September 21, 2025 in Santa Clara, California. Kavin Mistry / Getty ImagesIt's the second time Bosa has suffered a season-ending knee injury. In the 2020 season, Bosa suffered a torn ACL in Week 2 and was placed on injured reserve.
He is considered one of the best defensive players in the league and is one of the highest-paid defenders in the NFL after signing a record-setting five-year $170 million contract extension with the 49ers in 2023.
"You don't just replace a guy like Nick," Shanahan said. "Everyone has to get better."
The Niners have been missing several of their biggest stars with tight end George Kittle on injured reserve after hurting his hamstring in the season opener, No. 1 receiver Brandon Aiyuk on the physically unable to perform list recovering from knee surgery, and quarterback Brock Purdy missing two games with a toe injury.
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