The Cleveland Guardians (81-71) roll into Friday’s matchup with the Minnesota Twins (66-86) looking to extend a seven-game winning streak. The contest starts at 8:10 p.m. ET on MNNT and CLEG with the Twins listed as -123 favorites on the moneyline to stop the Guardians’ streak.
Cleveland has not named a starter for this contest, while Minnesota is projected to send Pablo Lopez to the mound.
Twins vs. Guardians Odds
Twins odds to win: -123 Guardians odds to win: +103 Spread: Twins -1.5 Total: 8 runsTwins vs. Guardians Promo Codes
Game Time and Information
Date: Friday, September 19, 2025 Time: 8:10 p.m. ET TV: MNNT and CLEGWho Will Win Twins vs. Guardians?
Twins and Guardians Betting Trends
The Twins have compiled a 39-47 record in games they were listed as the moneyline favorite (winning 45.3% of those games).
When playing as moneyline favorites with odds of -123 or shorter, Minnesota has a record of 30-28 (51.7%).
The Guardians have entered the game as underdogs 85 times this season and won 40, or 47.1%, of those games.
This season, Cleveland has won 30 of its 64 games, or 46.9%, when it’s the underdog by at least +103 on the moneyline.
The Twins have played in 151 games with a set over/under, and have combined with their opponents to go over the total 72 times (72-72-7).
So far this season, the Guardians and their opponents have hit the over in 63 of their 150 games with a total.
Twins Stats & Insights
The Twins have the No. 18 offense in MLB action scoring 4.3 runs per game (653 total runs).
Minnesota averages 1.2 home runs per game to rank 11th in MLB action with 182 total home runs.
The Twins have the 22nd-ranked batting average in the majors (.240).
Minnesota strikes out 8.3 times per game to rank 15th in the majors.
The 8.6 strikeouts per nine innings compiled by the Twins pitching staff ranks 12th in the majors.
Minnesota has a 4.66 team ERA that ranks 25th across all MLB pitching staffs.
Guardians Stats & Insights
The Guardians have scored the 27th-most runs in the league this season with just 594 (3.9 per game).
Cleveland ranks 21st in Major League Baseball with 157 home runs.
The Guardians rank 29th in MLB with a team batting average of just .226.
Cleveland ranks 14th with an average of 8.3 strikeouts per game.
The Guardians have an 8.5 K/9 this season as a pitching staff, which ranks 15th in the big leagues.
Cleveland pitchers have a combined ERA of 3.75 ERA this year, fifth-best in baseball.
Twins Key Players to Watch
The Twins will send Lopez (5-4) to the mound to make his 14th start of the season. He is 5-4 with a 2.64 ERA and 71 strikeouts through 71 2/3 innings pitched.
Byron Buxton leads Minnesota in home runs with 31, runs batted in with 76 and his batting average of .270 is also best on his team.
Trevor Larnach has 122 hits and an OBP of .327 to go with a slugging percentage of .409 this season.
Brooks Lee is slashing .242/.292/.379 this season for the Twins.
Kody Clemens is batting .213 with an OBP of .287 and a slugging percentage of .449 this season.
Guardians Key Players to Watch
Jose Ramirez has racked up a team-best batting average of .282, and leads the Guardians in home runs (29) and runs batted in (80).
Steven Kwan has 27 doubles, a triple, 10 home runs and 53 walks while batting .272.
Kyle Manzardo is batting .240 with 17 doubles, two triples, 26 home runs and 47 walks.
Angel Martinez has 22 doubles, two triples, 11 home runs and 21 walks while batting .230.
Twins and Guardians Injuries
Twins: Christian Vázquez: 10 Day IL (Shoulder), Anthony Misiewicz: 15 Day IL (Shoulder), David Festa: 15 Day IL (Shoulder), Justin Topa: 15 Day IL (Oblique), Alan Roden: 60 Day IL (Thumb), Ryan Jeffers: 7 Day IL (Head), Matt Wallner: day-to-day (Back)
Guardians: Lane Thomas: 10 Day IL (Foot), Nic Enright: 15 Day IL (Elbow), Ben Lively: 60 Day IL (Forearm), John Means: 60 Day IL (Elbow), Andrew Walters: 60 Day IL (Lat), Will Brennan: 60 Day IL (Forearm), Sam Hentges: 60 Day IL (Shoulder)
Twins vs. Guardians Prediction
Score Prediction: Twins 5, Guardians 4 Total Prediction: Under 8 runsHow to Bet on Twins vs. Guardians
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