The agency warned that intensifying strikes on Gaza City’s Zeitun neighbourhood are putting remaining residents in grave danger.
He said residents have little to no access to food and water under heavy bombardment.
Media restrictions in Gaza make independent verification of casualty figures difficult.
Hamas earlier condemned what it called “aggressive” Israeli ground incursions.
Israeli officials have previously rejected such claims, insisting they follow international law.
The area, one of Gaza’s most densely populated, has suffered over 22 months of war.
Ghassan Kashko, sheltering with his family in a school, said they “don’t know the taste of sleep.”
Israel’s war expansion plans have drawn international condemnation and domestic opposition.
The civil defence said 13 of Saturday’s victims were shot while waiting for food aid.
Israel’s offensive has claimed over 61,000 Palestinian lives, per Gaza’s health ministry- AFP
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