Deep space exploration requires a paradigm shift in astronaut medical support toward Earth-independent medical operations. Currently, astronauts rely on real-time communication with ground-based medical providers. However, as the distance from Earth increases, so do communication delays and disruptions. Deep space exploration crews will need to autonomously detect, diagnose, treat, and prevent medical conditions. One potential solution is to augment the long duration exploration crew’s knowledge, skills, and abilities with a digital clinical decision support system, or CDSS. The Exploration Medical Capability (ExMC) element of NASA’s Human Research Program is investigating the feasibility
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