Chennai, Dec 28 (IANS) Researchers at the Indian Institute of Technology (IIT) Madras and Mandi have metabolically engineered the plant cells of Nothapodytes nimmoniana to increase the production of Camptothecin, which is used to treat cancer. Using computational tools, researchers at IIT Madras’ Plant Cell Technology Lab developed a genome-scale metabolic model for N. nimmoniana plant cells. The team experimentally validated the overexpression of an enzyme predicted by the model, leading to the development of a 5-fold high camptothecin-yielding cell line of N. nimmoniana in comparison to the untransformed plant cell line. This can be a major boost to produce cancer-treating drugs as Camptot
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