USC Trojans (6-0) travel to take on the No. 21 Notre Dame Fighting Irish (5-2) on Saturday. Led by reigning Heisman Trophy winner Caleb Williams, USC enters this matchup looking to keep pace in the race for the College Football Playoff. The Trojans are coming off a 43-41 triple overtime win over Arizona last week. Notre Dame entered the season with high hopes, but lost its second game of the season last week to Louisville, falling 33-20 to the Cardinals. This is one of the most storied rivalry games in college football, and the Irish have won four of the last five meetings and hold a 48-37-5 advantage in the all-time series.
Notre Dame vs. USC odds, while the over/under is 60.5 points. Before making any USC vs. Notre Dame picks or bets, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor. 
Having lost twice in the last three games, the Fighting Irish (6-2) bounced back against their longtime rivals from the West Coast in a big way. Watts had two of Notre Dame's three first-half picks against Williams and then a 15-yard scoop-and-score with 3:27 left to add an exclamation point.
"Obviously, we were coming off a loss to Louisville," Watts said. "I was kind of angry from that. This was a big rivalry game. I just wanted to come out and dominate."
Benjamin Morrison had Notre Dame's other interception of the half, leading to Audric Estime's 1-yard plunge that put Notre Dame ahead 24-3. A week after wiping out a 17-point deficit to beat Arizona in overtime, the Trojans (6-1) had no such comeback in them.
Williams had only been intercepted once, but he was sacked four times by the Fighting Irish and finished with 199 yards passing and a TD. His hopes of becoming just the second two-time Heisman winner along with Ohio State's Archie Griffin took a hit.
Branch quickly established himself as one of the most dynamic players in college football, as he scored two receiving touchdowns and two special teams touchdowns in USC's first four games.
Branch caught 13 passes for 178 yards in four games and is averaging 22.5 yards per punt return and 28.5 yards per kickoff return.
Branch has lived up to his decorated billing, as he entered the season as the country's top wide receiver recruit and a top-10 overall in the ESPN recruiting rankings.
This is a massive loss for the USC secondary, and now Bryson Shaw will take his place. 
Although Williams was seen leaving to the locker room in tears, hopefully, this is nothing too significant. We'll provide you with more once it comes out. 
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