By JOSH DUBOW AP Pro Football WriterSANTA CLARA — Christian McCaffrey gained 142 yards from scrimmage and scored a touchdown in his first g...

Christian McCaffrey ran for 89 yards and a touchdown and the San Francisco 49ers overcame a horrible first-half stretch from quarterback Bro...

SANTA CLARA — Brock Purdy threw an opening-drive touchdown pass to Jauan Jennings, duping all into thinking this “Monday Night Football” aff...

The San Francisco 49ers host the Carolina Panthers on Monday Night Football in a key battle for NFC playoff positioning.

The 49ers are hosting the Carolina Panthers at Levi’s Stadium on Monday night with improved position in the NFC playoff hunt on the line.Ca...

The Underdog promo code NEWSWEEK unlocks a $100 bonus for Panthers vs. 49ers, NBA and NFL games.

Week 12 concludes with a fun 49ers vs Panthers Monday Night Football matchup where there are plenty of NFL DFS picks to choose from on BN Fa...

Justine Lindsay claims she was cut from the Panthers for being transgender.

The 49ers and Panthers are both alive in the NFC playoff picture. Which team will grab a crucial win on Monday Night Football?49ers...

SANTA CLARA – On display now at the Pro Football Hall of Fame is a memento from the 49ers’ last game, only it’s the Arizona Cardinals’ jerse...

Will George Kittle pay out his Week 12 anytime TD player prop when the San Francisco 49ers clash with the Carolina Panthers on Monday at...

The Carolina Panthers (6-5) hit the gridiron on Monday at 8:15 p.m. ET at Levi’s Stadium against the San Francisco 49ers (7-4). Below, we h...

No. 10 Alabama decimated Eastern Illinois 56-0 at home Saturday in a game that saw the Crimson Tide’s depth on full display before the Iron...

The NFL schedule makers, in their infinite, algorithmic wisdom, have given us a Monday night curiosity.The 49ers, I get — big brand, big na...

SANTA CLARA — Calm, cool and collected? Bryce Young makes the placid Brock Purdy look like a rabble-rouser at the podium.That’s not what th...