INDIANAPOLIS – Time for another inspiring reminder about Brock Purdy’s rise from NFL irrelevancy.It’s been three years and 10 months since...

The San Francisco 49ers (10-4) will visit the Indianapolis Colts (8-6) on Monday at 8:15 p.m. ET. Keep scrolling for DFS analysis.49ers v...

Aiyuk’s behavior has led some to publicly express concern.

Once 7-1, the Colts have lost five of six and are desperate for a win. The 49ers have won four straight to improve to 10-4. We’ve got the ke...

Here's how the 49ers could end up with a playoff bye.

There's more about Brandon Aiyuk the Niners aren't telling us.

SANTA CLARA – The 49ers’ path to and through the NFC playoffs could be dictated by tonight’s matchup in Seattle, where the Seahawks host the...

His first 49ers game back on the airwaves is set to come on Dec. 28 versus the Bears.

With Greg Papa on screen on the KNBR youtube channel wearing a broad smile and clean shaven for the first time in months, it was announced t...

SANTA CLARA — Holiday mail has arrived, at least in the form of social-media questions from 49ers fans ahead of Monday night’s visit to the...

SAN JOSE – It’s fair to say that tight end George Kittle and the San Francisco 49ers are welcome back at SAP Center to watch a San Jose Shar...

SANTA CLARA — The San Francisco 49ers have successfully navigated the minefield.Despite the injuries that piled up like unpaid parking tick...

Sunday offered Jeffery Simmons little to celebrate.

By MICHAEL MAROTINDIANAPOLIS (AP) — Indianapolis Colts coach Shane Steichen prefers being the aggressive play-caller.He likes taking chanc...

Things are looking good in terms of injuries for the 49ers coming out of a 37-24 win over the Tennessee Titans, but the status of wide recei...