Wideout Brian Thomas is looking at a matchup against the 31st-ranked passing defense in the league (250.7 yards allowed per game) in Week 1...

There was no on-field Christmas joy for Indianapolis.

Before Philip Rivers' first home game with the Colts following his stunning un-retirement at the age of 44, the father of 10 seemingly share...

INDIANAPOLIS – Here is how the 49ers (11-4) graded in Monday night’s 48-27 win over the host Colts (8-7):PASS OFFENSE: ABrock Purdy threw...

It wasn’t so long ago there were those among the fan base and the media openly wondering if giving Brock Purdy a five-year contract worth a...

The 44-year-old grandfather looked like he was throwing the football without a thumb. He had been retired for five years, presumably spendin...

The 49ers’ turbocharged offense led them to a 48-27 win over the Indianapolis Colts on Monday night, giving them a fifth consecutive victory...

By MICHAEL MAROT AP Sports WriterINDIANAPOLIS — Brock Purdy and the San Francisco 49ers kept winning and did their neighbors to the south a...

But do style points count in late December?Not one bit.The 49ers kept the good times rolling on Monday Night Football, dismantling the Col...

Philip Rivers sure looked like the Philip Rivers of old for a while – but it wasn’t enough.

Linebacker Eric Kendricks will make his 49ers debut Monday night against the Indianapolis Colts as will Jordan James, a fifth-round draft pi...

Philip Rivers and the Indianapolis Colts face Christian McCaffrey and the San Francisco 49ers on Monday Night Football.

Week 16 concludes this evening, with the Colts taking on the 49ers on Monday Night Football.How to Watch Monday Night Football: Colts vs...

The Sleeper promo code NEWSWEEKXL will earn new users a $100 bonus to play on Colts vs. 49ers and NFL games this week.

Monday Night Football brings an interconference matchup that puts the San Francisco 49ers on the road against the Indianapolis Colts. This g...