An experimental prostate cancer drug improved the survival of hospitalised COVID-19 patients in Brazil in a clinical trial, researchers reported on Tuesday on medRxiv ahead of peer review. The drug, proxalutamide being developed by Kintor Pharmaceuticals, blocks the effects of androgen hormones by inactivating their "receptors" on cell surfaces. Before the spikes on the surface of the coronavirus can break into cells and infect them, they must be "primed" by a protein called TMPRSS2, which is regulated by androgen receptors, explained study co-author John McCoy of Applied Biology Inc. In the Brazil trial, 645 hospitalised COVID-19 patients who were breathing on their own received either pro
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