Novel lncRNA, Caren, counteracts heart failure progression ...Middle East
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Researchers have identified a novel lncRNA, Caren, that is abundantly expressed in cardiomyocytes. It enhances energy production by increasing mitochondria in cardiomyocytes, and inhibits activation of the DNA damage response protein ATM, resulting in improvement of cardiac dysfunction. Caren RNA in cardiomyocytes is reduced by aging and hypertension, which can lead to heart failure, and markedly reduced in the hearts of heart failure patients. Caren activation could lead to new heart failure therapies.
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