US researchers have unveiled a significant upgrade to the CRISPR gene editing system, which, unlike its predecessor, can target specific genes with high precision and make completely reversible changes. The new gene editing technology, developed by Whitehead Institute Member Jonathan Weissman and University of California San Francisco assistant professor Luke Gilbert, is called CRISPRoff. It is capable of controlling a gene with laser-like precision, while leaving the broader strand of DNA unchanged. Furthermore, the edits are not only stable enough to be inherited through hundreds of cell divisions but are also fully reversible. “We
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