Can I take painkillers before or after a COVID-19 vaccine? Don't take them before a shot to try to prevent symptoms, but if your doctor agrees, it's OK to use them afterward if needed. The concern about painkillers is that they might curb the very immune system response that a vaccine aims to spur. Vaccines work by tricking the body into thinking it has a virus and mounting a defense against it. That may cause temporary arm soreness, fever, muscle aches or other symptoms of inflammation _ signs the vaccine is doing its job. Some research suggests that certain painkillers including ibuprofen (Advil, Motrin and other brands) might diminish the immune system's response. A study on mice suggest
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