Just before 12:30 p.m., the California Highway Patrol responded to a report that a vehicle heading east on I-80 drove off the road near the Highway 113 interchange.
The driver, a 56-year-old woman from Dixon, died at the scene, the CHP said. The passenger, a 65-year-old man from Vacaville, died while en route to the hospital.
A witness reported the driver appeared to be asleep at the wheel before the crash, officers said. It's unknown if DUI was a factor and the crash remains under investigation.
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