The news was revealed as part of the streamer's new UK slate unveiled at the Edinburgh TV Festival this week.
Whilst Netflix hasn't yet confirmed a release date, we do know that filming is due to kick off later this year in autumn.
The drama is based on Mackie's 2021 debut, a number one Sunday Times bestseller, which follows Grace Bernard, the overlooked daughter of billionaire social climber Simon Artemis. Born of an affair her father claims not to remember, Grace is left with her mother to fend for themselves.
On the previous announcement of Taylor-Joy in the lead role, author Mackie had praised her as the "most perfect fit" for Grace.
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Netflix describes the series as "the ultimate tale of revenge. Ambitious in scale, beautiful, filmic, and murderous." The streamer adds that Grace is "a modern day Gatsby, a Tom Ripley," playing dirty because "the game isn't fair," with the money "a nice bonus".
How To Kill Your Family was announced as part of a wide-ranging UK commissioning slate that also includes The Unheard, starring Kate Winslet and Maxine Peake, two Top Boy spin-offs featuring Barry Keoghan and Jasmine Jobson, and a new comedy from Derry Girls creator Lisa McGee.
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