The BBC One soap is to introduce the half-brother and niece of Denise Fox (Diane Parish), amid her ongoing battle with acute myeloid leukaemia, an aggressive form of blood cancer.
Due to the risk of infection, Denise is effectively cut off from the outside world - apart from the occasional visitor, who has to wear full PPE.
Spoilers released today (11 August) reveal that next week, another devastating blow is dealt when doctors explain that her treatment has not been working as well as they had hoped.
The Fox-Trueman family had previously reached out to her younger sister Daphne and mum Emerald to have their stem cells checked, though unfortunately neither were a match.
But could the introduction of the newcomers change everything?
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A statement from the soap teased that the clan will be "left reeling" by Kim Fox's (Tameka Empson) shocking discovery of the Larsons, and that "their introduction is far from straightforward."
Speaking of his casting, Colquhoun said: "I am thrilled to be finally moving to Walford after all these years, and the welcome I’ve received has been phenomenal.
Frempong added: "I am extremely excited to be joining EastEnders! I have watched the show for as long as I can remember and have such vivid memories of gathering around the TV with my family, especially at Christmas, to watch all the drama unfolding on the Square, so it feels pretty surreal to now be a part of the action!
Executive producer Ben Wadey said it was "great to delve into this wider family network."
"We're delighted to welcome Christopher and Krysstina to the cast as we bring two new faces to Walford.”
EastEnders confirms major castings as Nicola Mitchell's family move to Walford - including Beyond Paradise and Battlestar Galactica legendEastEnders legend Charlie Brooks tipped for Janine Butcher return in "explosive" autumn storylineEastEnders confirms Zoe Slater exit as legendary character tipped to be killed off
Visit our dedicated EastEnders page for all the latest news, interviews and spoilers.
Check out more of our Soaps coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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