While fertility decline is often linked to changes in egg number or quality, the uterus also becomes less receptive to an implanting embryo with age. The new research suggests that changes in the bacteria living there may be part of the reason.
The findings, published Thursday (Aug. 6) in the journal Cell Host & Microbe, suggest that the uterine microbiome could be a promising target for treating age-related infertility. However, experts who were not involved in the study cautioned that the research is still preliminary.
"The microbiome can be influenced by many factors, including genetics, diet, geography, environmental exposures and other lifestyle practices," he told Live Science in an email, "which is why it's important to validate these findings across diverse populations before developing broadly applicable treatments."
With age, the lining of the uterus typically becomes less receptive to implantation, lowering the chance of pregnancy. (Image credit: BSIP / Contributor vis Getty Images)
"One finding that surprised us was that overall microbial diversity did not change markedly across the different age groups," study co-author Dr. Rong Li, deputy director of the Department of Obstetrics and Gynecology at Peking University Third Hospital in Beijing, said in a statement. "Instead, the major differences involved particular bacterial species."
To better understand the effect of these bacteria on the uterus, the team isolated five Lactobacillus species and tested how they interacted with uterine cells. L. gasseri stood out because it attached strongly to uterine cells, and this attachment was associated with reduced inflammation and lower damage from oxidative stress. The bacterium also produced large amounts of exopolysaccharides (EPS), a type of sugar molecule.
Then, the researchers ran tests in older female mice (roughly equivalent to a middle-aged woman) to see whether introducing L. gasseri or LG-EPS to the vaginal canal could affect the aging uterus. After four weeks of daily vaginal treatment with either the bacterium or the postbiotic, the mice had fewer signs of uterine aging, less inflammation and higher embryo implantation rates than the untreated animals did. (That said, the team did not measure how much of each treatment actually reached the uterus.)
Further experiments suggested that the postbiotic works by modifying a signaling pathway that helps control cell growth and tissue repair. This pathway was overactive in aged mice and uterine cells, but treatment helped to normalize its activity. Blocking a key protein in the same pathway eliminated the treatment's effects.
RELATED STORIESRobles said postbiotic treatments could be especially interesting because they may be easier to manufacture than treatments containing live bacteria. "If confirmed in future studies, these treatments could potentially be used alongside IVF to improve the uterine environment before embryo transfer," he suggested.
"The reproductive tract is a delicate ecosystem, and introducing or eliminating certain bacteria could have unintended consequences," Robles said. "We do not fully understand what constitutes a 'healthy' uterine microbiome. As such, any intervention should be approached with caution."
This article is for informational purposes only and is not meant to offer medical advice.
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