Bryan Johnson, the centimillionaire biohacker, is pivoting in his live-forever strategy. This week, he claimed to have “cloned” himself — reprogramming stem cells to create newborn versions of his cells in a petri dish, which, he hopes, might one day be used to grow replacement organs. Having begun by trying to make his body 18 again, he is now attempting to manufacture youth outside it.
Johnson first beamed into my life in Miami in November 2023, when he gave a keynote address remotely at a psychedelics and longevity conference after going viral earlier that year. “Travel is really disruptive to sleep and to diet,” he said, wearing a t-shirt bearing the words “DON’T DIE.” He hadn’t attended in person because the algorithm tasked with continuously analysing his biometric data and reducing his biological age (yes, he had subjugated his health to the cold, hard logic of a machine) had apparently vetoed a three-hour disruption to his circadian rhythm with the coast-to-coast trip.
In the video call, Johnson — who made $300m (£225m) from the 2013 sale of his payment services company, Braintree, which owned Venmo — recounted some of his outlandish experiments as part of his $2m (£1.5m)- a-year quest for everlasting life. “I did, in fact, receive one litre of plasma from my 17-year-old son,” he said, joking about holding him captive in a tiny basement room by way of rebuking headlines about him that are “disconnected from reality”.
Johnson’s extreme “Project Blueprint” regime – his longevity protocol, which is now also a brand – entered public consciousness when Bloomberg published an article in January 2023, titled: “How to Be 18 Years Old Again for Only $2 Million a Year”, in which he lifted the lid on the spectacular expense and all-consuming effort within his obsessive odyssey to become 18 again.
The near-unfathomable account of his 5am wake-ups, seven daily creams, weekly acid peels and laser therapy, avoidance of sunlight, cauliflower gruel lunches and constant stool testing went viral. Johnson became the Peter Pan poster boy for a longevity movement that was swiftly becoming mainstream.
There have been many outré experiments (including the whole plasma thing) that have kept Johnson firmly in the ever-weirder zeitgeist since. In the Netflix documentary on his crusade, Don’t Die, released at the beginning of last year, he likens his efforts to winning Olympic gold for health (yes, he has his own “Rejuvenation Olympics” leaderboard), while, more endearingly perhaps, he is also shown attempting to learn how to do the splits.
During my first interaction with Johnson, he told me over Zoom that he had just received Botox injections in his penis. “It increased blood flow,” Johnson said of the Botox, also noting he was measuring his nighttime erections with some sort of futuristic contraption and subjecting his penis to painful shockwaves in an effort to strengthen his pelvic floor. “It increased penile length [and gave me] stronger erections… I perform better sexually than I have in my entire life.”
Since then, we have had several exchanges over email, and our relationship, if you can call it that, culminated towards the end of last year in him accusing me of being an “NPC”, meaning “non-player character (NPC)”, a gaming term that’s become an internet slang insult for someone lacking independent thought.
I didn’t interact with Johnson for some time after that, but my health-conscious aunt often sent me his latest Instagram clips decrying the “evil” of sugary ultra-processed food (UPF) companies and strongly suggesting that he holds the skeleton key to a life that is not only healthier but happier. (Start by purchasing his £40 Blueprint-branded extra virgin olive oil, and then pay £659 monthly for his “Medium Stack” including metabolic protein powder and 8g of fibre “to promote healthy digestion”, plus the haircare and skincare protocol products, obviously.)
Johnson’s Blueprint routine includes 5am wake-ups, seven daily creams, weekly acid peels and laser therapy, avoidance of sunlight, cauliflower gruel lunches and constant stool testing (Photo: Dustin Giallanza)But Johnson was not always glugging back extra virgin and operating at peak ability. At the time he sold Braintree, he was, by his own admission, “overweight and depressed” after years of poor diet, eating up to 150g of sugar per day. He wanted to become an Adonis. First, he left an unhappy marriage and the Mormon church he had been raised in. Then he took the first steps towards joining what he calls the healthiest 0.1 per cent of humanity. In 2020, he fired “Evening Bryan” and eliminated compulsive evening eating by enshrining his last feed at 11am, thus fasting for 20 hours every day.
In 2021, when his “chronological” age was 44, but his biological age was 36, he sought to totally remove his impulsive self from his decision-making processes and regimented his actions in line with what his body needed “through the regular measurement of hundreds of biomarkers.” Effectively, he put his body under algorithmic management.
And it seemed to work. Certainly, he has become somewhat easier on the eye, even if he can look ghastly pale, presumably from his lack of sunlight. But more importantly, he claims his body “in many ways runs like” an 18-year-old’s.
Now he was hurtling towards anti-ageing and “longevity escape velocity”, and like many other right-leaning figures, psychedelics became his latest obsession in 2025. (Johnson celebrated Donald Trump’s 2024 election victory, saying: “I am with you … in making America the healthiest, most vibrant, and strongest nation in the world.”)
At the conference, I first saw Johnson; he had spoken in passing about taking ketamine intravenously while testing his neuroimaging technology for his other company, Kernel, as one casually does. But in November 2025, he took five grams of psilocybin mushrooms (a so-called heroic dose that is often enough to launch you into hyperspace) on an X livestream to ascertain the potential longevity benefits of tripping, and evidently to demystify the process for the psychedelic-curious.
I reported on the spectacle for Wired, after spending part of my 32nd birthday watching his son Talmage, the musician Grimes, and Salesforce CEO Marc Benioff join him for a strange five-hour trip. It’s fair to say Johnson was not happy with my piece. He decried how he had been “harpooned” by critics quoted in my article who dared to suggest there may have been elements of ego enrichment and self-indulgence at play.
“Here’s what’s going on: when someone violates a tribe’s norms, the tribe’s priests don’t try to understand the new behavior, they seek to delegitimize the actor in order to protect their own status and try and claim superiority,” he told his 1.7 million followers on X. “Go build something cool. Redefine boundaries. Push past people’s comfort zone. When people squawk, understand they’re NPCs chirping but it’s really just a song they’re singing called progress.”
After more than a million people watched him plunge into the throes of a high-dose mushroom trip, Johnson also announced that Kate Tolo, the 30-year-old former employee turned co-founder, who had always been a curious character at his side, was now his girlfriend.
‘The 45-year-old isn’t just a longevity guru, but a psychedelic Pied Piper, and one that may well be ahead of the curve in the health-optimising and ‘consciousness-maxxing’ era,’ says Mattha Busby (Photo: Dustin Giallanza)“Kate feels like land to me after being adrift and searching for 25 years,” he wrote. “At this point, Kate and I have nearly become one person. We have entire conversations with a single look, sound, gesture or image.” Days later, he posted an erotic tale which captured the spirit of their transhuman-inspired love affair: “Goosebumps spread like a wildfire across her body. Her hypothalamus stimulates the release of GnRH which tells the pituitary gland to wake up her reproductive system.” Romantic.
Tolo was again at his side for his next public psychedelic voyage in March, this time with “the God molecule”, 5-MeO-DMT, perhaps the most potent of all psychedelics, and which is being developed to treat depression.
My aunt had tipped me off about his plans, fascinated as ever by his bizarre ventures. Johnson looked more nervous than he had with the mushrooms and for good reason given the speed with which the drug he was about to take can collapse consciousness. He said part of the reason he was embarking on the trip was because his brain remained stubbornly at the anatomical age of 42, and he wanted to see if 5-MeO-DMT could help de-age it.
Johnson shared my Rolling Stone article on the event approvingly, this time. “When I started Don’t Die in 2021, we evaluated all the scientific evidence for the most powerful anti-aging therapies,” he wrote next to a screenshot of the piece. “Psychedelics were nowhere to be found. A wild turn of events that they’re now front and center for us.”
Now Johnson wasn’t just a longevity guru, but a psychedelic Pied Piper, and one that may well be ahead of the curve in the health-optimising and “consciousness-maxxing” era that is now befalling us. His mission steadfastly continues, but despite his unprecedentedly public psychedelic use, any immortal sheen may be losing its lustre.
Last month, Johnson revealed that he had been diagnosed with autoimmune gastritis, announcing that “my stomach is eating itself.” It was a rare admission of mortality from a man trying to turn death into an engineering problem to solve and it seemed to trigger his effort to create new organs. My aunt will no doubt send me whatever comes next.
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