Steve Tandy's side are in Durban for the final set of summer fixtures in the new Nations Championship.
South Africa, meanwhile, are top of the Southern Hemisphere tables after confident victories over England and Scotland.
Read more: Nations Championship TV schedule
The game takes place at Hollywoodbets Kings Park in Durban, South Africa.
What time is South Africa v Wales kick-off?
Check out the Nations Championship TV schedule with our comprehensive guide.
What TV channel is South Africa v Wales on?
Rugby experts and former players will provide plenty of build-up to the big game in the run-up to kick-off.
There is also Welsh language coverage on S4C from 4pm.
Fans can tune in to watch all the action live and on the move via a range of device, including smartphones and tablets via the ITVX app.
Is South Africa v Wales on radio?
BBC Radio 5 Live Sports Extra 3 is available on DAB radio or you can tune into the station via most TV packages. You can also listen to BBC Radio 5 Live Sports Extra 3 online via the BBC website or BBC Sounds app.
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South Africa v Wales odds
In working partnership with the Radio Times, bet365 has provided the following betting odds for this event:
bet365 odds: South Africa (1/500) v Wales (33/1)*
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Check out more of our Sport coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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