Steve Tandy's side head to Estadio San Juan de Bicentenario as the Northern Hemisphere table toppers after a 39-24 victory over Fiji last weekend.
The visitors will know that Argentina, who were beaten by Scotland in the first round of the Nations Championship fixtures, will be a much tougher test.
Read more: Nations Championship TV schedule
The game takes place at Estadio San Juan de Bicentenario in San Juan, Argentina.
What time is Argentina v Wales kick-off?
Check out the Nations Championship TV schedule with our comprehensive guide.
What TV channel is Argentina v Wales on?
Rugby experts and former players will provide plenty of build-up to the big game in the run-up to kick-off.
Every match of the tournament will be shown live across ITV platforms.
Fans can tune in to watch all the action live and on the move via a range of device, including smartphones and tablets via the ITVX app.
Is Argentina v Wales on radio?
BBC Radio 5 Live Sports Extra is available on DAB radio, or you can tune into the station via most TV packages. You can also listen to BBC Radio 5 Live Sports Extra online via the BBC website or BBC Sounds app.
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Argentina v Wales odds
In working partnership with the Radio Times, bet365 has provided the following betting odds for this event:
bet365 odds: Argentina (1/14) v Wales (7/1)*
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Check out more of our Sport coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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