Skubal (5-4) struck out the side in the first inning for the second time in his career and left after 96 pitches. The left-hander allowed five hits and walked two. His only blemish came on rookie Henry Bolte's third homer, a leadoff shot in the third that cut it to 2-1.
Kyle Finnegan pitched a scoreless sixth following Skubal, and Drew Anderson allowed Shea Langeliers' RBI single for an unearned run in the seventh. Jacob Waguespack closed it out with two perfect innings.
Detroit broke it open with a four-run sixth after Lopez retired the first two batters.
Lopez was charged with four runs on five hits for the Athletics, who have lost four straight and eight of nine.
Athletics LHP Jeffrey Springs (3-8, 5.79) starts Wednesday opposite Tigers RHP Troy Melton (4-1, 2.05).
AP MLB: apnews.com/hub/mlb
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