The iconic Mexico City ground has been a fortress for the tournament co-hosts, who haven't lost in their last 26 matches at the stadium, while injuries and the altitude look set to make the Three Lions' job an even tougher one.
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The hosts have won every game at the tournament so far and are yet to concede a goal but will they end England's World Cup dreams?
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If Tuchel's side can weather that storm successfully and even land a few punches of their own in the opening exchanges, then they could pull off one of the great World Cup wins.
Radio Times says... Mexico 1-3 England
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