The crash happened shortly after 4 p.m. along the eastbound lanes of Highway 50 near Ice House Road, the California Highway Patrol's Placerville office said.
The front-seat passenger of the vehicle died at the scene, the CHP said. Two children were seated in the back of the SUV.
The cause of the crash remains under investigation.
Caltrans said Highway 50 near Riverton and Ice House Road was under one-way traffic control following the crash.
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