Embattled Louisiana Sen. Cassidy Loses Primary as Trump-Backed Challenger and State Treasurer Head to a Runoff ...Middle East

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Senator Bill Cassidy, Republican of Louisiana, attends a meeting to consider the nomination of Robert F. Kennedy, Jr. to be Secretary of Health and Human Services on Capitol Hill in Washington, D.C., on February 4, 2025. —Saul Loeb—AFP/Getty Images

A challenger endorsed by President Donald Trump, Louisiana Rep. Julia Letlow, secured the largest share of the vote, underlining the President’s influence. State Treasurer John Fleming came in second.

In an election night speech, Cassidy did not directly mention Trump, but appeared to allude to the President and in particular his false claims that the 2020 election was stolen from him.

Trump congratulated Letlow on beating Cassidy in a post on Truth Social late Saturday.

The primary battle has been rife with intra-party tension. While Senate Majority Leader John Thune and the National Republican Senatorial Committee backed Cassidy, other prominent Republican leaders including Trump and Louisiana Gov. Jeff Landry threw their support behind Letlow. In January, Trump announced his endorsement of Letlow before she had officially launched her campaign, calling her “a Great Star” who “has ALWAYS delivered for Louisiana.” While he didn’t mention Cassidy in the post, Trump’s endorsement of the sitting senator’s opponent was a clear snub. 

Cassidy has long been a subject of the President’s ire. The Louisiana senator was among the seven Republicans who voted to convict Trump in his second impeachment trial back in 2021. Cassidy, a physician and proponent of vaccines, has also been one of few politicians within Trump’s party to push back against the changes the Administration has made to the nation’s vaccine policies. During the confirmation hearings for Robert F. Kennedy Jr., who is one of the country’s most notorious vaccine skeptics, as Secretary of Health and Human Services, Cassidy expressed concerns about Trump’s decision to nominate him for the role, though the Louisiana senator still ultimately voted to confirm him.

“For months, Senator Bill Cassidy (of the GREAT State of Louisiana!), a very disloyal person whose ‘TRUMP’ Endorsement got him elected, but later voted to impeach ‘President Trump’ on what has now proven to be a total Hoax and Scam, has stood in the way of Robert F. Kennedy Jr.’s Nominee, Casey Means, for the important position of U.S. Surgeon General,” Trump said in the post.

While the balance of power in Washington is at stake in the upcoming November midterm elections, Cassidy’s seat is unlikely to flip; the Cook Political Report ranks it as “Solid Republican.”

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