The Bills will host the Detroit Lions for Thursday Night Football in week two of the upcoming NFL season.
The rest of Buffalo’s schedule including their week one contest has not been announced. This week two clash with the Lions will be the first regular season game at the new Highmark Stadium.
This Bills-Lions battle is scheduled for Thursday, September 17.
The Bills and Lions have played 13 times total with Buffalo leading the all-time series, 8-4-1, and having won the last five contests. Their most recent tilt was a 48-42 shootout going in the Bills’ favor.
The rest of the NFL schedule is set to be released on Thursday, May 14, at 8 pm.
#Bills are 8-4-1 overall against the Lions.
Buffalo has won their last five contests against Detroit.
Also–their first matchup against each other in 1972 was a 21-21 tie–it was the last game EVER at the War Memorial. #BillsMafia t.co/kdi8ZVA6c8
— Ian Mills (@IanMillsTV) May 11, 2026
NFL Schedule Release: Bills to host Lions in week two Thursday Night Football Clash WHEC.com.
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