The Giants, who've lost eight of their past nine games, managed only three hits and struck out 13 times.
Keaton Winn then replaced starter Adrian Houser (0-4). After a walk, groundout and pop-out left runners at second and third with two outs, lefty Matt Gage replaced Winn, and France pinch-hit for Sung-Mun Song.
Houser put together his best performance in seven starts with San Francisco. He gave up two runs (one earned) on three hits in six-plus innings.
Xander Bogaerts tagged reliever Ryan Walker for a two-run homer to left in the eighth inning, making it 5-1. It was Bogaerts' team-leading seventh home run of the season.
San Francisco's run came on an opposite-field homer by Rafael Devers, his third HR of the season and first since April 8.
Up next
The Giants host Pittsburgh on Friday night.
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