Alvarez (1-0), recalled earlier Sunday from Triple-A Rochester, allowed three hits, struck out five and walked none.
Miles Mikolas replaced opener PJ Poulin with two on and two outs in the first inning and worked four innings. He allowed four hits, struck out four, walked one and lowered his ERA from 11.49 to 9.15.
The Giants went 0 for 10 with runners in scoring position and left 10 men on base.
Washington scored three runs in the fifth. Nasim Nuñez beat out a drag bunt and stole second. Ruiz hit a line drive to left-center, and left fielder Heliot Ramos couldn't come up with the diving catch as Nuñez scored. Mead then lined a first-pitch changeup to left for a two-run homer.
Up next
Giants: RHP Landon Roupp (3-1, 2.38 ERA) opposes Dodgers RHP Yoshinobu Yamamoto (2-1, 2.38) in the series opener at San Francisco on Tuesday.
Nationals: RHP Jake Irvin (1-2, 6.16) starts against Braves RHP Reynaldo Lopez (1-0, 2.18) in the first of a four-game series on Monday.
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