But there's one role in his career that the acting legend has played more times than any other: Jack Tiberius Byrnes.
Focker-in-Law will see De Niro, Ben Stiller and Owen Wilson all return to their roles from the previous three films, with Ariana Grande the most high profile new addition to the cast and John Hamburg directing after co-writing each of the earlier instalments.
Focker-in-Law has confirmed a release date of Wednesday 25 November 2026 – so at time of writing there's still more than 6 months to go.
Production on the film took place last year, beginning in August and continuing until early November.
Focker-in-Law cast: Who's returning and who's joining the cast?
Robert De Niro as Jack ByrnesBen Stiller as Gaylord "Greg" FockerAriana Grande as Olivia JonesOwen Wilson as Kevin RawleyBlythe Danner as Dina ByrnesTeri Polo as Pam Byrnes FockerSkyler Gisondo as Henry FockerBeanie Feldstein as Samantha FockerEduardo Franco as TBC
As mentioned above, Robert De Niro, Ben Stiller and Owen Wilson will each be reprising their memorable roles as Jack Byrnes, Greg Focker and Kevin Rawley, while Teri Polo and Blythe Danner are also back as Pam Byrnes Focker and Dina Byrnes.
However, by far the most headline addition is pop superstar and Academy Award-nominated Wicked actor Ariana Grande. She takes on the role of Olivia Jones, who is described as "a former FBI hostage negotiator" and "Henry's girlfriend and potential bride-to-be." Her character would appear to be the driving force of the new film.
We don't have an official synopsis for the film at this stage – with the only details revealed so far being a very brief tagline that simply reads "The circle of trust just got bigger."
We'll post a more comprehensive synopsis when we get it.
Focker-in-Law trailer
The trailer begins with Jack putting Olivia through his infamous lie detector test – and that's just the start of the tribulations she has to face as she prepares for life as part of this madcap family. You can check it out below:
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