Walker finished 3 for 5 with three runs scored, while Joey Loperfido, Yainer Diaz and Christian Vázquez each added three hits as Houston matched a season high with 11 runs.
The Astros struck first in the opening inning. Jeremy Peña doubled and scored when José Altuve lined an RBI single to center. Walker followed later in the inning with an RBI single that brought home Yordan Alvarez for a 2-0 lead.
Joey Loperfido hit a ground-rule double down the left-field line that scored Carlos Correa, and Diaz had a two-RBI single to stretch the Astros lead to 7-0 in the fourth.
Loperfido added an RBI single in the sixth before Vázquez delivered his second RBI double of the game. Alvarez later singled home another run as Houston scored three times in the inning to make it 10-0.
Oakland managed five hits and went 0 for 2 with runners in scoring position. Luis Morales (0-2) surrendered five runs, eight hits, and six walks in the loss.
Up next
RHP Lance McCullers Jr. (1-0, 1.29 ERA) gets the start for the Astros, while LHP Jacob Lopez (0-1, 6.75 ERA) takes the mound for the Athletics in the final game of the series.
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