Michael (David Morrissey) is the headmaster of a prestigious private school, while his wife Sarah and their daughter Alana (Emma Appleton) are also teachers at the same famed institution.
After waiting in the hope that she will walk through their front door, they eventually contact the police and a missing persons investigation is launched.
But is Michael simply a product of his environment? Or is there a far more sinister reason for his chilling behaviour?
Over the past eight years, the detective has grown close to the victim's mother, Carol, but as time continues to pass with no further developments, she "appears to be losing faith in her".
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Torchwood legend Eve Myles reveals why dark new drama "took its toll a bit"Is Gone based on a true story?
The Sarah Polly case in Gone is entirely fictional, but the drama is partly inspired by the work of former Detective Superintendent Julie Mackay of Gloucestershire Police, who solved the cold case murder of 17-year-old Melanie Road, more than three decades on.
Myles told Radio Times that Melanie's story "is touched upon, the backdrop to the story is very much Julie's story. But it doesn’t domineer this series, and our story veers somewhere completely different".
Melanie was sexually assaulted and stabbed 26 times before her body was discovered by a milkman and his 10-year-old son at 5.30am in front of some garages, a short distance from her home.
But in 2016, Christopher Hampton – who was 32 at the time of Melanie’s murder – was sentenced to life imprisonment after pleading guilty to her murder. Then 64, he was ordered to serve a minimum of 22 years behind bars.
Investigators had held a DNA profile of Melanie's suspected killer since 1995, but there had been no match on the national database – that was until DNA from Hampton's daughter was taken following a criminal damage charge, and added to the system.
"It's a fascinating story, it's an extraordinary case to follow," Eve Myles told Radio Times.
"So I'm really pleased that it was spotted, and that George [Kay, who write the series] and [director] Richard [Laxton] have highlighted it. It's a story that should absolutely be celebrated, and Julie should be celebrated."
"A few people approached Rob and me about the rights to our book and we ended up working with George Kay," the former detective, who acted as a consultant on the series with Murphy, told Radio Times magazine.
As for similarities between her and Myles's character, while they share a profession, McKay was in a very different place in her life when she was in the thick of the Melanie Road investigation.
"Annie is her own person; she's not me at that stage. I was a single mother with three kids – my life was chaotic. Annie is gutsy and intuitive; she's like a dog with a bone, refusing to let things go, even when it’s against the rules."
"I was lucky enough to make contact with her and have many calls with her, and meet her. She was very generous with her time and her information," she added.
Gone begins airing on Sunday 8 March on ITV1 and ITVX.
Check out more of our Drama coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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