Swollen feet, a complete loss of appetite and near-total exhaustion spark increasingly worried glances from her friends, with Dr Turner ordering blood tests to get to the bottom of her latest bout of ill health. And in tonight's episode (Sunday 15 February), the results arrive: chronic kidney disease.
"But it takes them," Dr Turner adds, suspecting the condition has developed suddenly rather than over a long period.
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Call the Midwife's Trixie makes painful admission about her marriage to MatthewCall the Midwife boss teases prequel cast – including new and original favouritesYet Sister Monica Joan remains resistant to intervention. "Maybe I do not care to go on for a long time," she says, despite Nurse Crane's reassurance that her time is not yet up. Without treatment, though, the prognosis is bleak.
Reflecting on the theme of change at the Radio Times Covers Party 2026, Thomas said: "I've had a lot of these stories in mind for a long time, and change has generated so many of our stories over the past few years.
While she described the transition as feeling "organic", she also admitted it has been deeply emotional.
"I think we’ve all cried our eyes out at different times because things never will be the same again," she said. "But the whole thing with Call the Midwife, like life itself, it's a process of constant evolution for our characters and also for the stories."
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"Many of the things that I depict in that episode I have experienced in life, so it felt strangely personal," she explained. "But I think the driving thing was to do a really good job. We're only getting the chance to wrap up this iteration once, and it has to be done to the highest possible standard.
And Thomas isn't the only one feeling the impact of the season. In an interview with Radio Times magazine, Judy Parfitt – now 90 and part of the show since its very beginning – admitted that filming the latest block proved particularly demanding, both physically and emotionally.
She then went on to talk about just how much she's loved spending time with the character all these years: "I've always wanted to play a nun because I was educated by nuns – and I loved Monica Joan's character. The way she was written as quirky and offbeat was a joy; she spoke in a different way from everybody else, which is hell to learn. People come to her for advice but she’s also highly strung, very sensitive. If she's thrown off-course, she loses the plot.
Call the Midwife season 15 continues on BBC One and BBC iPlayer on Sunday at 8pm.
Check out more of our Drama coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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