The Truth About Over-the-Counter GLP-1 Patches, According to Doctors ...Saudi Arabia

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For many people, GLP-1 medications (which are prescribed to manage type 2 diabetes or for weight loss) are literally life-saving. A 2024 study published in Proceedings of the National Academy of Sciences estimates that GLP-1s can prevent more than 42,000 deaths each year, including 11,000 deaths among people with type 2 diabetes. 

Until recently, GLP-1s have only been available as injections, which must be self-administered, most commonly, once a week. But last month, GLP-1s were introduced in pill form, a major innovation. This has left many people wondering: Are GLP-1 patches next? After all, patch medications are already available for certain medications for lowering blood pressure, pain management and hormone therapy. 

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Unfortunately, Dr. Dovec says it’s not likely to happen anytime soon. “GLP-1 medications are particularly challenging to deliver through the skin. These drugs are relatively large peptide molecules, which makes transdermal absorption difficult,” she says, explaining that the reason the new semaglutide pill works is that it has specific absorption enhancers and strict dosing conditions. But patches are different. According to Dr. Dovec, patch medications only work when drugs have smaller molecules, which is not the case with semaglutide. 

Dr. Hector Perez, MD, a bariatric surgeon and an advisor at BestSurgeons.com, an online database that helps patients in the US and Mexico locate qualified surgeons, agrees that GLP-1 patches are unlikely because the drug’s molecules are so large. Additionally, he says that there aren’t any existing scientific studies showing that a GLP-1 patch would work. If GLP-1 patches were viable, Dr. Perez explains that pharmaceutical companies would be clambering to fund and produce them. There’s a reason why that’s not happening.

Related: Oprah Winfrey Reveals Unexpected Effect of GLP-1 Medication on Her Health

What About Over-The-Counter GLP-1 Patches?

“Overall, save your money. [Over-the-counter drugs] being labeled as GLP-1 patch is simply a way to catch the consumers’ attention without taking into account the lack of safety and efficacy these products provide,” notes Dr. Rami Lutfi, MD, a bariatric and general surgeon and medical director for bariatric and general surgery at Carrum Health.

Dr. Lutfi explains that true GLP-1 medications are backed by clinical trials and are FDA-approved. That is not the case with over-the-counter GLP-1 patches. “Products currently being marketed as ‘GLP-1 patches’ are not delivering GLP-1 medications like semaglutide or tirzepatide through the skin. Instead, they typically contain supplements such as berberine, L-glutamine, chromium, resveratrol, garcinia cambogia or plant extracts,” emphasizes Dr. Dovec. 

With all this in mind, if you are considering taking a GLP-1 medication, talk to your healthcare provider about being prescribed one that’s FDA-approved instead of falling for the clever marketing of GLP-1 patches. And if you are prescribed a GLP-1, don’t expect to be given a patch anytime soon.

Related: What To Know About the ‘Pink Salt Trick,’ the New Weight Loss Method Everyone’s Talking About

Sources:

Poll: 1 in 8 Adults Say They Are Currently Taking a GLP-1 Drug for Weight Loss, Diabetes, or Another Condition, Even as Half Say the Drugs are Difficult to Afford. Kaiser Family Foundation.Pandey A., Ye, Yang, Wells, C.R., et al. (2024). Estimating the lives that could be saved by expanding access to weight-loss drugs.Proceedings of the National Academy of Sciences. 121(43):e2412872121Consequences of Obesity. Centers for Disease Control and PreventionDr. Betsy Dovec, MD, FACS, bariatric surgeon with HCA Florida HealthcareDr. Hector Perez, MD, bariatric surgeon and an advisor at BestSurgeons.com, an online database that helps patients in the US and Mexico locate qualified surgeonsDr. Sameer Murali, MD, medical director of obesity medicine at Memorial Hermann Health SystemDr. Rami Lutfi, MD, bariatric and general surgeon and medical director for bariatric and general surgery at Carrum Health

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