The hosts are chasing promotion in League Two but will put that on hold as they go in search of another upset.
Watch Salford City v Leyton Orient live on TNT Sports via discovery+ on Amazon Prime Video
The O's, who are themselves in the play-off race in the third tier, edged past non-league Tamworth in the last round.
RadioTimes.com has rounded up everything you need to know about how to watch Salford City v Leyton Orient on TV and online.
Salford City v Leyton Orient will take place on Friday 5th December 2025.
Salford City v Leyton Orient kick-off time
Salford City v Leyton Orient will kick off at 7:30pm.
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How to live stream Salford City v Leyton Orient online
You can watch the match on TNT Sports via discovery+ Premium monthly pass without signing up to a contract.
discovery+ is the new streaming home of TNT Sports, showing events including live Premier League, UEFA Champions League, Premiership Rugby, UFC, Boxing and MotoGP. Learn more here: discoveryplus.com
Listen to Salford City v Leyton Orient on radio
BBC Radio 5 Live Sports Extra 3 is available on DAB radio or you can tune into the station via most TV packages. You can also listen to BBC Radio 5 Live Sports Extra 3 online via the BBC website or BBC Sounds app.
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Salford City v Leyton Orient odds
In working partnership with the Radio Times, bet365 has provided the following betting odds for this event:
bet365 odds: Salford City (8/5) Draw (13/5) Leyton Orient (29/20)*
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*Odds subject to change. 18+. T&Cs apply. GambleAware.org. Note – The bonus code RT365 does not change the offer amount in any way.
Check out more of our Sport coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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