It’s time for Week 13 of the 2025 season.
With just 2 weeks to go, numerous teams across the country still have plenty of motivation to turn in good performances down the stretch.
As always, this piece will focus on 5 underdogs to cover the spread for this upcoming weekend. We went 4-1 last week for a profit of 2.91 units.
5 ATS underdog predictions
Here are 5 predictions for underdogs to cover the spread this week along with the best-in-market college football odds:
Missouri +7.5 over Oklahoma
Oklahoma was pretty fortunate to get an outright win last week against Alabama. Bill Connelly’s postgame win expectancy metric said the Sooners had less than a 5% chance to win. Oklahoma is returning home after back-to-back huge road wins over Tennessee and Alabama. I think the Sooners will win, but they’ve had a knack for playing close games all season. Their offense isn’t quite good enough to separate even if their defense plays a dominant game. I think Mizzou keeps this within the number.
Pick: Missouri +7.5 (-110 at bet365)
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Virginia Tech +17.5 over Miami
Virginia Tech has a new head coach in James Franklin. While he won’t be involved in the game-planning for this game against the Hurricanes, I expect to see some sort of a boost from Virginia Tech players who are hoping to impress their new head coach in this game against the Canes. It’s also typically a good idea to fade Miami as a favorite in ACC games. Under Mario Cristobal, Miami is 7-14-1 against the spread as a favorite in conference play.
Pick: Virginia Tech +17.5 (-105 at BetMGM)
Charlotte +44 over Georgia
This is a hold-your-nose pick. Georgia could obviously pick its final score in this matchup, but the Bulldogs have generally not covered in spots like this under Kirby Smart. UGA is 0-6-1 against the spread as a favorite of 38+ during his tenure. Charlotte’s offense has been touch-and-go this season, but the Chanticleers did manage to average over 5 yards per play in 2 of their last 3 contests. Given Georgia’s tendencies, I think something like 42-0 or 45-3 is in play for this game. UGA also has Georgia Tech and potentially an SEC Championship Game matchup on deck.
Pick: Charlotte +44 (-110 on Fanatics)
North Carolina +7 over Duke
Both of these teams are coming off of disappointing losses, but I like the Tar Heels to have a better bounce-back game. North Carolina has to win this game in order to keep bowl hopes alive and there’s no shame in losing by a couple scores to Wake Forest on the road. UNC’s defense has been solid over the second half of the season and I think we’ll see another good effort on Saturday at home. Duke has completely cratered down the stretch, losing 3 of its last 4 games. I’m not sure how much juice the Blue Devils have this season.
Pick: North Carolina +7 (-115 on bet365)
Appalachian State +5.5 over Marshall
App State got blasted by Playoff-hopeful James Madison last week. I like this as a bounce-back spot for the Mountaineers against a Marshall team that’s been far from perfect this year. This is also an opportunity to sell high on the Thundering Herd a week after they picked up a double-digit victory over a Georgia State team that is in the conversation for worst defense in FBS. I think App State is live to win outright.
Pick: App State +5.5 (-110 on Fanatics)
Spenser Davis
Saturday Down South • November 20, 2025 at 6:58pm
Pick Odds AwayPointSpread +7.5 Spread CFB • Missouri Tigers @ Oklahoma Sooners -110 on Bet365 SCHEDULED • 11/22/2025 See all 5 picks Tally (Win %) 0-0-0 (0%) Money Meter $0.00 ROI 0.0% Betslip #1763665094621-16bd-694Predicting 5 underdogs to cover the spread in Week 13 Saturday Down South.
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