Purdy had practiced on a limited basis the past three weeks as he worked his way back from the toe injury but was expected to carry a bigger load this week, with the goal of him starting on Sunday at Arizona.
Purdy initially injured the toe in the season opener at Seattle and missed the next two games. He struggled in a loss to Jacksonville on Sept. 28 and has missed the past six games.
After seeing him increase his practice load the past few weeks, the hope is he can get back to the form he had before the injury. Purdy helped the 49ers reach the NFC title game as a rookie in 2022 and the Super Bowl the following season, when he was a finalist for the AP NFL MVP award.
"He looks like Brock," running back Christian McCaffrey said. "He's throwing well. He's running well. He looks good."
Pearsall, the team's first-round draft pick in 2024, had 20 catches for 327 yards in four games this season.
Rookie defensive tackle Alfred Collins also was set to be limited at practice after missing last week's game with a hip injury.
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