This variation on the premise sees cynical doctor Martin Best (Charles) move from the bustling city of Boston, Massachusetts, to a quaint fishing village on the East Coast, where he is enthusiastically greeted by close-knit locals.
Best Medicine made headlines last month when it was announced that original Doc Martin star Clunes would appear, playing the father of his original character.
If you're intrigued by Best Medicine, check out the trailer for the US remake below:
In addition to Clunes and lead actor Charles, whose past credits include The Good Wife, Unbreakable Kimmy Schmidt and The Handmaid's Tale, there are a number of other familiar faces in the Best Medicine cast.
Abigail Spencer (Suits, Grey's Anatomy), Josh Segarra (She-Hulk, Abbott Elementary), Annie Potts (Young Sheldon, Ghostbusters) and rising star Cree (Big Sky, And Just Like That...) round out the regulars on the upcoming comedy-drama.
Best Medicine is currently scheduled to premiere in the US on FOX in January, with episodes to stream afterwards on Hulu, but there's no word yet on what the UK rollout will look like.
Best Medicine premieres on FOX in January. UK broadcast TBC.
Check out more of our Drama coverage or visit our TV Guide and Streaming Guide to find out what's on. For more TV recommendations and reviews, listen to The Radio Times Podcast.
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