The narrative has jumped four years into the future, which means we pick up with the Skeldale gang in 1945, just as the war draws to a close.
And you can also expect plenty more "heartwarming human and animal tales" across the six episodes.
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All Creatures Great and Small star reveals James's recovery has been a "process"All Creatures Great and Small season 6 confirmed to "further" relationship between Siegfried and TristanThe six-part season will premiere on Thursday 25th September 2025 at 9pm on 5.
The remaining episodes will air weekly.
All Creatures Great and Small season 6 cast: Who's returning? And who's new?
Nicholas Ralph as James HerriotRachel Shenton as Helen HerriotCallum Woodhouse as Tristan FarnonSamuel West as Siegfried FarnonAnna Madeley as Mrs Hall
There's also Patricia Hodge as Mrs Pumphrey (alongside Derek the dog, who plays Tricki Woo), Imogen Clawson as Jenny Alderson and Tony Pitts as Richard Alderson.
The new guest stars are as follows:
Lucy-Jo Hudson (Coronation Street', Hollyoaks, Wild at Heart)Chris Gascoyne (Coronation Street, The Feud, Patience)Gaia Wise (The Dead of Winter, The Lord of the Rings: The War of the Rohirrim)Jonathan Hyde (The Brutalist, Titanic)Philip Martin Brown (Waterloo Road, Tinker, Taylor, Soldier, Spy)All Creatures Great and Small season 6 plot: What will happen?
"Helen’s enjoying time with young Jimmy and Rosie but has big changes afoot at Heston to contend with. Tristan returns from several years at war and will have to re-adjust to life back home in Darrowby.
Season 6 will see the characters "re-connect with each other and find their renewed purpose, looking to a brighter future as the world around them starts to breathe again".
Speaking to RadioTimes.com about Tristan's trials and tribulations this season, Woodhouse said that "a lot of things definitely come to the forefront this time".
"And that has definitely been rectified this time around."
"He spends the series trying to push a lot of things down and try and make everyone think that he's absolutely fine," he added. "He's the usual Tristan that we all know and expect, but we’re sort of drip fed... that things aren't all OK."
All Creatures Great and Small season 6 trailer: When can I watch it?
Enjoy the heartwarming trailer below.
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