Entering Wednesday’s matchup with the New York Yankees (89-68), the Chicago White Sox (58-99) are on a three-game losing streak. The contest starts at 7:05 p.m. ET on YES and CHSN with the Yankees listed as -375 favorites, while the are +300 underdogs who may be heading for a fourth straight defeat.
Chicago has not named a starter for this contest, while New York is expected to send Max Fried to the mound.
Yankees vs. White Sox Odds
Yankees odds to win: -375 White Sox odds to win: +300 Spread: Yankees -1.5 Total: 8 runsYankees vs. White Sox Promo Codes
Game Time and Information
Date: Wednesday, September 24, 2025 Time: 7:05 p.m. ET TV: YES and CHSNWho Will Win Yankees vs. White Sox?
Yankees and White Sox Betting Trends
The Yankees have won 59% of the games this season when they were favored on the moneyline (79-55).
New York has not played a game with moneyline odds of -375 or shorter.
The White Sox have won 57, or 37%, of the 154 games they’ve played as underdogs this season.
Chicago has not entered a game this season as a bigger underdog on the moneyline than the +300 odds on it winning this game.
The Yankees have played in 156 games with set over/under, and have combined with opponents to go over the total 74 times (74-76-6).
The White Sox and their opponents have hit the over in 70 of their 157 games with a total this season.
Yankees Stats & Insights
The Yankees score the most runs in baseball (819 total, 5.2 per game).
The New York Yankees have hit an MLB-leading 263 home runs, averaging 1.7 per game.
The Yankees rank 12th in the majors with a .250 batting average.
New York’s batters strike out nine times per game, the 28th-most in the majors.
The pitching staff for the Yankees has a collective nine K/9, the fourth-best in MLB.
New York has the 15th-ranked team ERA among all MLB pitching staffs (3.97).
White Sox Stats & Insights
The White Sox have scored the 27th-most runs in the league this season with just 620 (3.9 per game).
Chicago’s 157 home runs rank 23rd in Major League Baseball.
The White Sox have a team batting average of just .232 this season, which ranks 27th among MLB teams.
Chicago ranks 17th in MLB in strikeouts per game with an average of 8.4 Ks per contest.
The White Sox average the 22nd-most strikeouts per nine innings (8.1) in the majors this season.
Chicago has the 19th-ranked ERA (4.23) in the majors this season.
Yankees Key Players to Watch
Fried (18-5) gets the starting nod for the Yankees in his 32nd start of the season. He’s put together a 2.92 ERA in 188 1/3 innings pitched, with 182 strikeouts.
Aaron Judge leads New York in home runs with 49, runs batted in with 105 and his batting average of .325 is also best on his team.
Cody Bellinger has 154 hits and an OBP of .328 to go with a slugging percentage of .483 this season.
Trent Grisham has collected 113 base hits, an OBP of .346 and a slugging percentage of .467 this season.
Jazz Chisholm has 111 hits and an OBP of .337 to go with a slugging percentage of .490 this season.
White Sox Key Players to Watch
Miguel Vargas is hitting .230 with 32 doubles, two triples, 15 home runs and 52 walks.
Lenyn Sosa has shown his power as he paces his team with 21 home runs and 71 RBI, with a team-high .258 batting average.
Chase Meidroth has 15 doubles, five home runs and 45 walks while hitting .262.
Mike Tauchman is batting .263 with 17 doubles, a triple, nine home runs and 45 walks.
Yankees and White Sox Injuries
Yankees: Jonathan Loaisiga: 15 Day IL (Back), Brent Headrick: 15 Day IL (Forearm), Gerrit Cole: 60 Day IL (Elbow), Oswaldo Cabrera: 60 Day IL (Ankle), Clarke Schmidt: 60 Day IL (Forearm), Jake Cousins: 60 Day IL (Elbow)
White Sox: Luis Robert: 10 Day IL (Hamstring), Andrew Benintendi: 10 Day IL (Achilles), Bryan Hudson: 15 Day IL (Back), Martín Pérez: 15 Day IL (Shoulder), Elvis Peguero: 15 Day IL (Elbow), Miguel Castro: 60 Day IL (Knee), Ky Bush: 60 Day IL (Elbow), Prelander Berroa: 60 Day IL (Elbow), Drew Thorpe: 60 Day IL (Elbow)
Yankees vs. White Sox Prediction
Score Prediction: Yankees 5, White Sox 3 Total Prediction: Over 8 runsHow to Bet on Yankees vs. White Sox
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